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1

The Biochemical Basis of Vitamin A Production from Asymmetric Carotenoid β-Cryptoxanthin

Kelly, Mary E, Ramkumar, Srinivasagan, Sun, Weizhong, Colon Ortiz, Crystal, Kiser, Philip D, Golczak, Marcin, von Lintig, Johannes

Journal:

ACS Chemical Biology

Year:

2018

Language:

english

File:

PDF, 3.17 MB

english, 2018

2

Chemistry of the Retinoid (Visual) Cycle

Kiser, Philip D., Golczak, Marcin, Palczewski, Krzysztof

Journal:

Chemical Reviews

Year:

2014

Language:

english

File:

PDF, 20.08 MB

english, 2014

3

Shedding new light on the generation of the visual chromophore

Palczewski, Krzysztof, Kiser, Philip D.

Journal:

Proceedings of the National Academy of Sciences

Year:

2020

File:

PDF, 1.68 MB

2020

4

Structural basis for carotenoid cleavage by an archaeal carotenoid dioxygenase

Daruwalla, Anahita, Zhang, Jianye, Lee, Ho Jun, Khadka, Nimesh, Farquhar, Erik R., Shi, Wuxian, von Lintig, Johannes, Kiser, Philip D.

Journal:

Proceedings of the National Academy of Sciences

Year:

2020

File:

PDF, 1.86 MB

2020

5

Engineered zinc-binding sites confirm proximity and orientation of transmembrane helices I and III in the human serotonin transporter

Kellie J. White, Philip D. Kiser, David E. Nichols, Eric L. Barker

Journal:

Protein Science

Year:

2006

Language:

english

File:

PDF, 831 KB

english, 2006

6

Conformational change of human checkpoint kinase 1 (Chk1) induced by DNA damage

Han, Xiangzi, Tang, Jinshan, Wang, Jingna, Ren, Feng, Zheng, Jinhua, Gragg, Megan, Kiser, Philip, Park, Paul S.-H., Palczewski, Krzysztof, Yao, Xinsheng, Zhang, Youwei

Journal:

Journal of Biological Chemistry

Year:

2016

Language:

english

File:

PDF, 5.49 MB

english, 2016

7

LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3

Golczak, Marcin, Sears, Avery E, Kiser, Philip D, Palczewski, Krzysztof

Journal:

Nature Chemical Biology

Year:

2014

Language:

english

File:

PDF, 2.62 MB

english, 2014

8

Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor

Gulati, Sahil, Jin, Hui, Masuho, Ikuo, Orban, Tivadar, Cai, Yuan, Pardon, Els, Martemyanov, Kirill A., Kiser, Philip D., Stewart, Phoebe L., Ford, Christopher P., Steyaert, Jan, Palczewski, Krzysztof

Journal:

Nature Communications

Year:

2018

Language:

english

File:

PDF, 3.75 MB

english, 2018

9

Evidence for distinct rate-limiting steps in the cleavage of alkenes by carotenoid cleavage dioxygenases

Khadka, Nimesh, Farquhar, Erik R., Hill, Hannah E, Shi, Wuxian, von Lintig, Johannes, Kiser, Philip D

Journal:

Journal of Biological Chemistry

Year:

2019

File:

PDF, 3.05 MB

2019

10

Medullary cystic kidney disease type 1 in a large Native-American kindred

Kiser, Raymond L., Wolf, Matthias T.F., Martin, Jeffrey L., Zalewski, Isabella, Attanasio, Massimo, Hildebrandt, Friedhelm, Klemmer, Philip

Journal:

American Journal of Kidney Diseases

Year:

2004

Language:

english

File:

PDF, 113 KB

english, 2004

11

Rational tuning of visual cycle modulator pharmacodynamics

Kiser, Philip D, Zhang, Jianye, Badiee, Mohsen, Kinoshita, Junzo, Peachey, Neal S, Tochtrop, Gregory P, Palczewski, Krzysztof

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2017

Language:

english

File:

PDF, 11.74 MB

english, 2017

12

Studies on the Significance of Decreased Serum Sodium Levels Following the Clinical use of Mannitol

Tunner, William S., Kiser, Willian S., Mann, Philip

Journal:

The Journal of Urology

Year:

1965

Language:

english

File:

PDF, 160 KB

english, 1965

13

Vector-Host Interactions of Culiseta melanura in a Focus of Eastern Equine Encephalitis Virus Activity in Southeastern Virginia

Molaei, Goudarz, Armstrong, Philip M., Abadam, Charles F., Akaratovic, Karen I., Kiser, Jay P., Andreadis, Theodore G., Forrester, Naomi

Journal:

Year:

2015

Language:

english

File:

PDF, 1.37 MB

english, 2015

14

Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function

Kiser, Philip D., Zhang, Jianye, Sharma, Aditya, Angueyra, Juan M., Kolesnikov, Alexander V., Badiee, Mohsen, Tochtrop, Gregory P., Kinoshita, Junzo, Peachey, Neal S., Li, Wei, Kefalov, Vladimir J., P

Journal:

The Journal of General Physiology

Year:

2018

Language:

english

File:

PDF, 3.06 MB

english, 2018

15

Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing

Suh, Susie, Choi, Elliot H., Leinonen, Henri, Foik, Andrzej T., Newby, Gregory A., Yeh, Wei-Hsi, Dong, Zhiqian, Kiser, Philip D., Lyon, David C., Liu, David R., Palczewski, Krzysztof

Journal:

Nature Biomedical Engineering

Year:

2020

File:

PDF, 6.18 MB

2020

16

Preexisting crescentic glomerulonephritis in the renal allograft

Raymond L Kiser, David B Thomas, Kenneth Andreoni, Philip J Klemmer

Journal:

American Journal of Kidney Diseases

Year:

2003

Language:

english

File:

PDF, 560 KB

english, 2003

17

Characterization of human β,β-carotene-15,15′-monooxygenase (BCMO1) as a soluble monomeric enzyme

Kowatz, Thomas, Babino, Darwin, Kiser, Philip, Palczewski, Krzysztof, von Lintig, Johannes

Journal:

Archives of Biochemistry and Biophysics

Year:

2013

Language:

english

File:

PDF, 1.44 MB

english, 2013

18

Photic generation of 11-cis-retinal in bovine retinal pigment epithelium

Zhang, Jianye, Choi, Elliot H, Tworak, Aleksander, Salom, David, Leinonen, Henri, Sander, Christopher Lane, Hoang, Thanh V., Handa, James T., Blackshaw, Seth, Palczewska, Grazyna, Kiser, Philip D, Pal

Journal:

Journal of Biological Chemistry

Year:

2019

File:

PDF, 2.12 MB

2019

19

People, places, and events

Kowatz, Thomas, Babino, Darwin, Kiser, Philip, Palczewski, Krzysztof, von Lintig, Johannes

Journal:

Journal of Pediatric Health Care

Year:

1991

Language:

english

File:

PDF, 243 KB

english, 1991

20

Characterization of the Role of β-Carotene 9,10-Dioxygenase in Macular Pigment Metabolism

Babino, Darwin, Palczewski, Grzegorz, Widjaja-Adhi, M. Airanthi K., Kiser, Philip D., Golczak, Marcin, von Lintig, Johannes

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 3.84 MB

english, 2015

21

Structure and spectroscopy of alkene-cleaving dioxygenases containing an atypically coordinated non-heme iron center

Sui, Xuewu, Weitz, Andrew C., Farquhar, Erik R., Badiee, Mohsen, Banerjee, Surajit, von Lintig, Johannes, Tochtrop, Gregory, Palczewski, Krzysztof, Hendrich, Michael P., Kiser, Philip D

Journal:

Year:

2017

Language:

english

File:

PDF, 1.41 MB

english, 2017

22

The human mitochondrial enzyme BCO2 exhibits catalytic activity towards carotenoids and apocarotenoids

Thomas, Linda D, Bandara, Sepalika, Parmar, Vipul M, Srinivasagan, Ramkumar, Khadka, Nimesh, Golczak, Marcin, Kiser, Philip D, von Lintig, Johannes

Journal:

Journal of Biological Chemistry

Year:

2020

File:

PDF, 2.51 MB

2020

23

Ligand Binding Induces Conformational Changes in Human Cellular Retinol-Binding Protein 1 (CRBP1) revealed by atomic resolution crystal structures

Silvaroli, Josie A., Arne, Jason M., Chelstowska, Sylwia, Kiser, Philip D., Banerjee, Surajit, Golczak, Marcin

Journal:

Journal of Biological Chemistry

Year:

2016

Language:

english

File:

PDF, 3.50 MB

english, 2016

24

Partial Hospitalization

Best, Larry, Braun, Philip, Cuyler, Robert N., Kiser, Laurel, Lefkovitz, Paul M.

Journal:

Psychiatric Services

Year:

1992

Language:

english

File:

PDF, 450 KB

english, 1992

25

Retinoids and Retinal Diseases

Kiser, Philip D., Palczewski, Krzysztof

Journal:

Annual Review of Vision Science

Year:

2016

Language:

english

File:

PDF, 3.37 MB

english, 2016

26

Structural biology of 11- cis- retinaldehyde production in the classical visual cycle

Daruwalla, Anahita, Choi, Elliot H., Palczewski, Krzysztof, Kiser, Philip D.

Journal:

Biochemical Journal

Year:

2018

Language:

english

File:

PDF, 2.51 MB

english, 2018

27

Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cells

Montano, Monica M., Yeh, I-Ju, Chen, Yinghua, Hernandez, Chris, Kiselar, Janna G., de la Fuente, Maria, Lawes, Adriane M., Nieman, Marvin T., Kiser, Philip D., Jacobberger, James, Exner, Agata A., Law

Journal:

Breast Cancer Research

Year:

2019

File:

PDF, 2.22 MB

2019

28

The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision

Johannes von Lintig, Philip D. Kiser, Marcin Golczak, Krzysztof Palczewski

Journal:

Trends in Biochemical Sciences

Year:

2010

Language:

english

File:

PDF, 720 KB

english, 2010

29

Key enzymes of the retinoid (visual) cycle in vertebrate retina

Philip D. Kiser, Marcin Golczak, Akiko Maeda, Krzysztof Palczewski

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Year:

2012

Language:

english

File:

PDF, 1.29 MB

english, 2012

30

Structural basis of carotenoid cleavage: From bacteria to mammals

Sui, Xuewu, Kiser, Philip D., Lintig, Johannes von, Palczewski, Krzysztof

Journal:

Archives of Biochemistry and Biophysics

Year:

2013

Language:

english

File:

PDF, 4.03 MB

english, 2013

31

Structural and mechanistic aspects of carotenoid cleavage dioxygenases (CCDs)

Daruwalla, Anahita, Kiser, Philip D.

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Year:

2019

File:

PDF, 1.09 MB

2019

32

Impact of Retinal Disease-Associated RPE65 Mutations on Retinoid Isomerization †

Bereta, Grzegorz, Kiser, Philip D., Golczak, Marcin, Sun, Wenyu, Heon, Elise, Saperstein, David A., Palczewski, Krzysztof

Journal:

Year:

2008

Language:

english

File:

PDF, 6.21 MB

english, 2008

33

Catalytic mechanism of a retinoid isomerase essential for vertebrate vision

Kiser, Philip D, Zhang, Jianye, Badiee, Mohsen, Li, Qingjiang, Shi, Wuxian, Sui, Xuewu, Golczak, Marcin, Tochtrop, Gregory P, Palczewski, Krzysztof

Journal:

Nature Chemical Biology

Year:

2015

Language:

english

File:

PDF, 1.59 MB

english, 2015

34

Eyes on systems pharmacology

Chen, Yu, Kern, Timothy S., Kiser, Philip D., Palczewski, Krzysztof

Journal:

Pharmacological Research

Year:

2016

Language:

english

File:

PDF, 393 KB

english, 2016

35

Pathways and disease-causing alterations in visual chromophore production for vertebrate vision

Kiser, Philip D, Palczewski, Krzysztof

Journal:

Journal of Biological Chemistry

Year:

2020

File:

PDF, 1.31 MB

2020

36

Preparation and characterization of metal-substituted carotenoid cleavage oxygenases

Sui, Xuewu, Farquhar, Erik R., Hill, Hannah E., von Lintig, Johannes, Shi, Wuxian, Kiser, Philip D.

Journal:

JBIC Journal of Biological Inorganic Chemistry

Year:

2018

Language:

english

File:

PDF, 2.55 MB

english, 2018

37

Abnormal cannabidiol modulates vitamin A metabolism by acting as a competitive inhibitor of CRBP1

Silvaroli, Josie A, Widjaja-Adhi, Made Airanthi K., Trischman, Thomas, Chelstowska, Sylwia, Horwitz, Samantha, Banerjee, Surajit, Kiser, Philip D, Blaner, William S., Golczak, Marcin

Journal:

ACS Chemical Biology

Year:

2019

Language:

english

File:

PDF, 62.33 MB

english, 2019

38

Single particle cryoâEM of the complex between interphotoreceptor retinoidâbinding protein and a monoclonal antibody

Sears, Avery E., Albiez, Stefan, Gulati, Sahil, Wang, Benlian, Kiser, Philip, Kovacik, Lubomir, Engel, Andreas, Stahlberg, Henning, Palczewski, Krzysztof

Journal:

The FASEB Journal

Year:

2020

File:

PDF, 1.80 MB

2020

39

Enzyme That Makes You Cry–Crystal Structure of Lachrymatory Factor Synthase from Allium cepa

Silvaroli, Josie A., Pleshinger, Matthew J., Banerjee, Surajit, Kiser, Philip D., Golczak, Marcin

Journal:

ACS Chemical Biology

Year:

2017

Language:

english

File:

PDF, 946 KB

english, 2017

40

Membrane-binding and enzymatic properties of RPE65

Philip D. Kiser, Krzysztof Palczewski

Journal:

Progress in Retinal and Eye Research

Year:

2010

Language:

english

File:

PDF, 1.21 MB

english, 2010

41

The Biochemical Basis of Vitamin A 3 Production in Arthropod Vision

Babino, Darwin, Golczak, Marcin, Kiser, Philip D., Wyss, Adrian, Palczewski, Krzysztof, von Lintig, Johannes

Journal:

ACS Chemical Biology

Year:

2016

Language:

english

File:

PDF, 3.88 MB

english, 2016

42

Key Residues for Catalytic Function and Metal Coordination in a Carotenoid Cleavage Dioxygenase

Sui, Xuewu, Zhang, Jianye, Golczak, Marcin, Palczewski, Krzysztof, Kiser, Philip D.

Journal:

Journal of Biological Chemistry

Year:

2016

Language:

english

File:

PDF, 2.03 MB

english, 2016

43

Reappraisal of dioxygen binding in NOV1 crystal structures

Kiser, Philip D.

Journal:

Proceedings of the National Academy of Sciences

Year:

2017

Language:

english

File:

PDF, 603 KB

english, 2017

44

Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65

Choi, Elliot H, Suh, Susie, Sander, Christopher L, Hernandez, Christian J Ortiz, Bulman, Elizabeth R, Khadka, Nimesh, Dong, Zhiqian, Shi, Wuxian, Palczewski, Krzysztof, Kiser, Philip D

Journal:

Human Molecular Genetics

Year:

2018

Language:

english

File:

PDF, 62.58 MB

english, 2018

45

Publisher Correction: Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing

Suh, Susie, Choi, Elliot H., Leinonen, Henri, Foik, Andrzej T., Newby, Gregory A., Yeh, Wei-Hsi, Dong, Zhiqian, Kiser, Philip D., Lyon, David C., Liu, David R., Palczewski, Krzysztof

Journal:

Nature Biomedical Engineering

Year:

2020

File:

PDF, 531 KB

2020

46

Photic generation of 11-cis-retinal in bovine retinal pigment epithelium

Zhang, Jianye, Choi, Elliot H, Tworak, Aleksander, Salom, David, Leinonen, Henri, Sander, Christopher Lane, Hoang, Thanh V., Handa, James T., Blackshaw, Seth, Palczewska, Grazyna, Kiser, Philip D, Pal

Journal:

Journal of Biological Chemistry

Year:

2019

Language:

english

File:

PDF, 2.12 MB

english, 2019

47

Abnormal cannabidiol modulates vitamin A metabolism by acting as a competitive inhibitor of CRBP1

Silvaroli, Josie A, Widjaja-Adhi, Made Airanthi K., Trischman, Thomas, Chelstowska, Sylwia, Horwitz, Samantha, Banerjee, Surajit, Kiser, Philip D, Blaner, William S., Golczak, Marcin

Journal:

ACS Chemical Biology

Year:

2019

File:

PDF, 62.33 MB

2019

48

GENETIC BASIS OF DE NOVO APPEARANCE OF CAROTENOID ORNAMENTATION IN BARE-PARTS OF CANARIES

Gazda, Małgorzata Anna, Toomey, Matthew B, Araújo, Pedro M, Lopes, Ricardo J, Afonso, Sandra, Myers, Connie A, Serres, Kyla, Kiser, Philip D, Hill, Geoffrey E, Corbo, Joseph C, Carneiro, Miguel, Wittk

Journal:

Molecular Biology and Evolution

Year:

2020

File:

PDF, 1.08 MB

2020

49

Stereospecificity of Retinol Saturase: Absolute Configuration, Synthesis, and Biological Evaluation of Dihydroretinoids

Moise, Alexander R., Domínguez, Marta, Alvarez, Susana, Alvarez, Rosana, Schupp, Michael, Cristancho, Ana G., Kiser, Philip D., de Lera, Angel R., Lazar, Mitchell A., Palczewski, Krzysztof

Journal:

Journal of the American Chemical Society

Year:

2008

Language:

english

File:

PDF, 99 KB

english, 2008

50

Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism

Gulati, Sahil, Jastrzebska, Beata, Banerjee, Surajit, Placeres, Ángel L., Miszta, Przemyslaw, Gao, Songqi, Gunderson, Karl, Tochtrop, Gregory P., Filipek, Sławomir, Katayama, Kota, Kiser, Philip D., M

Journal:

Proceedings of the National Academy of Sciences

Year:

2017

Language:

english

File:

PDF, 1.16 MB

english, 2017

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